Piper Parajo and Sloane McBrute are two 13-year-old girls with very different lives but very similar secrets. At school, Piper is pretty and popular, upbeat and always willing to help out her friends, whereas Sloane is a loaner, smart and snarky but with zero friends and zero interest in having any. Outside of the classroom, Piper is strong, really strong, like ripping the doors off of cars strong. She longs to be a superhero and tries to use her powers to do good, even if she tends to leave a massive mess in her wake. Sloane on the other hand is smart, like evil-genius level smart, and in order to provide for her mother, she puts those smarts to the use of her villainous grandfather.
When a mission to steal an experimental technological device brings the two girls to face each other, the device sparks, and the two girls switch bodies! Now they must live in each others shoes as they figure out a way to switch back.